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The absence of GLP1R in normal and hyperplastic C cells of the thyroid clearly indicates that these tissues are unlikely targets for GLP1 analogs in humans

In infectious disease treatment, the EPR effect may likewise result in NP accumulation at the infection area due to improved vascular permeability and reduced lymphatic function in inflamed tissues [200]

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An independent assessment committee evaluated the endpoints and determined threshold criteria for clinically meaningful responses before the trials unblinding